Intranasal delivery of nerve growth factor attenuates aquaporins-4-induced edema following traumatic brain injury in rats
Traumatic brain injury (TBI) remains the leading cause of injury-related death and disability.
Brain edema, one of the most major complications of TBI, contributes to elevated intracranial
pressure, and poor prognosis following TBI. Nerve growth factor (NGF) appears to be a
viable strategy to treat brain edema and TBI. Unfortunately, due to its poor blood-brain
barrier (BBB) permeability, the clinical application of NGF has been greatly limited. We
previously demonstrated that intranasal NGF could bypass the BBB and distribute …
Brain edema, one of the most major complications of TBI, contributes to elevated intracranial
pressure, and poor prognosis following TBI. Nerve growth factor (NGF) appears to be a
viable strategy to treat brain edema and TBI. Unfortunately, due to its poor blood-brain
barrier (BBB) permeability, the clinical application of NGF has been greatly limited. We
previously demonstrated that intranasal NGF could bypass the BBB and distribute …
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